منابع مشابه
Studies on Thiamine Analocues
Several analogues of thiamine’ are known to compete with the vitamin when administered to animals. Thus, Woolley and White (1) have observed that pyrithiamine caused the manifestation of typical thiamine deficiency symptoms, which could be competitively overcome by the vitamin. The antivitamin effect of oxythiamine in mice has been reported by Soodak and Cerecedo (2). Cerecedo et al. (3, 4), co...
متن کاملHistochemical study on thiamine.
The authors have applied the thiochrome method for determining thiamine to histochemical investigations and could observe the localization of thiamine in cells and tissues (1-6). Independently of our study, v. Muralt (7) had already reported a investigation on histological pictures of thiamine in peri pheral nerves by the thiochrome method, which was however unavailable to the authors at that t...
متن کاملAction of the thiamine antagonist bacimethrin on thiamine biosynthesis.
Bacimethrin is an analog of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamine and inhibits the growth of Salmonella enterica serovar Typhimurium on a defined medium. Two classes of mutants that had increased bacimethrin resistance were isolated and characterized. Results showed that overexpression of the thi operon or specific lesions in thiD resulted in a bacimethrin-resi...
متن کاملEffects of thiamine deficiency and thiamine administration on the thiamine diphosphate-dependent enzymes in rat liver.
The activities of pyruvate and 2-oxoglutarate dehydrogenases were determined by a spectrophotometric method according to Massey, that of transketolase deter mined by Racker's method. The values of enzyme activity as well as the thiamine contents in the preparations were compared with those of the animals whose deficiencies were restored by thiamine administration. The thiamine deprivation resul...
متن کاملInhibition of Thiamine Pyrophosphate Utilization by Thiamine
The growth of a thiamine pyrophosphate auxotroph of Escherichi coli was inhibited by either thiamine or thiamine monophosphate, and the growth of a thiamine monophosphate auxotroph was inhibited by thiamine. The thiamine pyrophosphate-dependent oxidation of pyruvate was inhibited by thiamine with whole cells of the thiamine pyrophosphate auxotroph but not with cell extracts prepared from the sa...
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ژورنال
عنوان ژورنال: THE JOURNAL OF VITAMINOLOGY
سال: 1954
ISSN: 0022-5398
DOI: 10.5925/jnsv1954.1.27